Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels

Carbohydr Res. 2019 Oct 1:484:107778. doi: 10.1016/j.carres.2019.107778. Epub 2019 Aug 14.

Abstract

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells.

Keywords: Anti-inflammatory effect; Leguminosae; Mildiside A; Millettia dielsiana; Phenolic compound.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Survival
  • Isoflavones / chemistry
  • Isoflavones / pharmacology*
  • Lipopolysaccharides / adverse effects
  • Mice
  • Millettia / chemistry*
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Stems / chemistry
  • RAW 264.7 Cells
  • Secondary Metabolism*

Substances

  • Anti-Inflammatory Agents
  • Isoflavones
  • Lipopolysaccharides
  • Plant Extracts
  • Nitric Oxide