Optical Coherence Tomography of Choroid in Common Neurological Diseases

In Vivo. 2019 Sep-Oct;33(5):1403-1409. doi: 10.21873/invivo.11617.


The choroid is involved directly and indirectly in many pathological conditions such as age-related macular degeneration, myopia-related chorioretinal atrophy and central serous chorioretinopathy. Optical coherence tomography (OCT) has gradually become a fundamental part of modern resources in the hands of ophthalmologists. The enhanced depth imaging technique and swept-source OCT make a great contribution to conventional in vivo choroid assessment. This review focuses on the most common neurological conditions in which choroid assessment by OCT may provide help in early diagnosis and be used as an interdisciplinary follow-up tool. In order to avoid evaluation biases and misdiagnosis, the main and most common physiological and para-physiological conditions in which the choroid may show alterations are also reviewed.

Keywords: Alzheimer; Optical coherence tomography; Parkinson; Sturge–Weber syndrome; choroid; multiple sclerosis; phakomatoses; review.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Age Factors
  • Choroid / diagnostic imaging*
  • Choroid / pathology*
  • Circadian Rhythm
  • Diagnosis, Differential
  • Humans
  • Nervous System Diseases / diagnosis*
  • Nervous System Diseases / pathology*
  • Sex Factors
  • Tomography, Optical Coherence*