Abstract
We compared the abilities of young and senescent fibroblasts to take up and degrade [3H]ribonuclease A (native and oxidized), [3H]ribonuclease4-13, [3H]hemoglobin, [3H]glyceraldehyde-3-phosphate dehydrogenase, [3H]beta-galactosidase, [3H]glycogen phosphorylase, and [125I]serum albumin. The endocytic uptake of these proteins ranged from fluid-phase to predominantly absorptive. Intralysosomal degradation rates of the different endocytosed proteins varied by an order of magnitude, but in no case was there a difference between cultures of young and senescent fibroblasts.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging / metabolism*
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Cells, Cultured
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Endocytosis
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Fibroblasts / metabolism*
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Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism
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Glyceraldehyde-3-Phosphate Dehydrogenases / pharmacokinetics
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Hemoglobins / metabolism
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Hemoglobins / pharmacokinetics
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Humans
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Lysosomes / metabolism
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Phosphorylases / metabolism
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Phosphorylases / pharmacokinetics
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Proteins / metabolism*
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Proteins / pharmacokinetics
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Ribonuclease, Pancreatic / metabolism
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Ribonuclease, Pancreatic / pharmacokinetics
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Ribonucleases / metabolism
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Ribonucleases / pharmacokinetics
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Serum Albumin / metabolism
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Serum Albumin / pharmacokinetics
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Sucrose / metabolism
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Sucrose / pharmacokinetics
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beta-Galactosidase / metabolism
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beta-Galactosidase / pharmacokinetics
Substances
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Hemoglobins
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Proteins
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Serum Albumin
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Sucrose
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Glyceraldehyde-3-Phosphate Dehydrogenases
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Phosphorylases
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Ribonucleases
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Ribonuclease, Pancreatic
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beta-Galactosidase