2D Graphdiyne Oxide Serves as a Superior New Generation of Antibacterial Agents

Yana Zhang; Wenxin Liu; Yongjun Li; Ying-Wei Yang; Alideertu Dong; Yuliang Li

doi:10.1016/j.isci.2019.08.019

2D Graphdiyne Oxide Serves as a Superior New Generation of Antibacterial Agents

iScience. 2019 Sep 27:19:662-675. doi: 10.1016/j.isci.2019.08.019. Epub 2019 Aug 16.

Authors

Yana Zhang¹, Wenxin Liu¹, Yongjun Li², Ying-Wei Yang³, Alideertu Dong⁴, Yuliang Li⁵

Affiliations

¹ College of Chemistry and Chemical Engineering, Inner Mongolia University, 235 University West Street, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education,Inner Mongolia University, 235 University West Street, Hohhot 010021, China.
² Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, No. 2 North First Street, Zhongguancun, Beijing 100190, China. Electronic address: liyj@iccas.ac.cn.
³ International Joint Research Laboratory of Nano-Micro Architecture Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P.R. China; California NanoSystems Institute and Department of Chemistry & Biochemistry, University of California, Los Angeles, CA 90095, USA. Electronic address: ywyang@jlu.edu.cn.
⁴ College of Chemistry and Chemical Engineering, Inner Mongolia University, 235 University West Street, Hohhot 010021, China; Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education,Inner Mongolia University, 235 University West Street, Hohhot 010021, China. Electronic address: dongali@imu.edu.cn.
⁵ Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, No. 2 North First Street, Zhongguancun, Beijing 100190, China.

Abstract

Graphdiyne (GDY) as an emerging 2D carbon-network nanomaterial possesses many fascinating properties that lead to numerous exciting applications, but the use of GDY and its derivatives in the antibacterial field has not yet been discovered. In this study, we first report on the use and evaluation of GDY and graphdiyne oxide (GDYO) as antibacterial agents and propose the antibacterial mechanisms of GDY-based nanomaterials. GDYO has been synthesized via the surface oxidation of GDY, and the antibacterial activity of GDYO has been compared with that of GDY through a series of antibacterial tests. Surprisingly, surface oxidation endowed inert GDY with superior antibacterial capability against two representative bacterial models: Escherichia coli and Staphylococcus aureus. Antibacterial mechanism experiments disclose that the antibacterial function of GDYO is a result of reactive oxygen species-dependent oxidation stress when a dispersed GDYO suspension has a direct contact with bacteria especially under visible light irradiation.

Keywords: Chemical Synthesis; Materials Characterization; Nanomaterials.