Bone Quality Measured Using Calcaneal Quantitative Ultrasonography Is Reduced Among Children with HIV in Johannesburg, South Africa

Stephen M Arpadi; Cara B Thurman; Faeezah Patel; Jonathan J Kaufman; Renate Strehlau; Megan Burke; Stephanie Shiau; Ashraf Coovadia; Michael T Yin

doi:10.1016/j.jpeds.2019.07.018

Bone Quality Measured Using Calcaneal Quantitative Ultrasonography Is Reduced Among Children with HIV in Johannesburg, South Africa

J Pediatr. 2019 Dec:215:267-271.e2. doi: 10.1016/j.jpeds.2019.07.018. Epub 2019 Aug 29.

Authors

Stephen M Arpadi¹, Cara B Thurman², Faeezah Patel³, Jonathan J Kaufman⁴, Renate Strehlau³, Megan Burke³, Stephanie Shiau⁵, Ashraf Coovadia³, Michael T Yin⁶

Affiliations

¹ Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY. Electronic address: sma2@columbia.edu.
² Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.
³ Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Pediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ CyberLogic, Inc., New York, NY; Department of Orthopedics, The Mount Sinai Medical Center, New York, NY.
⁵ Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
⁶ Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.

Abstract

We evaluated bone quality among South African children with HIV over a 2-year period by quantitative ultrasound (QUS). Children with HIV have persistently lower bone quality compared with controls reflecting increased porosity, reduced strength, and possibly an increased short- and long-term risk of fracture.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Anti-Retroviral Agents / therapeutic use
Bone Density / physiology*
Calcaneus / diagnostic imaging*
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Female
HIV Infections / drug therapy
HIV Infections / physiopathology*
Humans
Longitudinal Studies
Male
South Africa / epidemiology
Ultrasonography

Substances

Anti-Retroviral Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding