Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report

Cardiol Young. 2019 Oct;29(10):1300-1301. doi: 10.1017/S1047951119001938. Epub 2019 Sep 2.

Abstract

A female neonate with in utero selective serotonin reuptake inhibitor exposure presented with bradycardia shortly after birth. Electrocardiography showed severe QT prolongation and second-degree atrioventricular block. Over time QT-times spontaneously normalised and genetic testing did not show mutations associated with long QT syndrome making maternal selective serotonin reuptake inhibitor usage the most likely explanation for the observed severe transient neonatal QT prolongation.

Keywords: Long QT syndrome; in utero exposure; neonate; paroxetine; selective serotonin reuptake inhibitor.

Publication types

  • Case Reports

MeSH terms

  • Electrocardiography
  • Female
  • Humans
  • Infant, Newborn
  • Long QT Syndrome / chemically induced*
  • Long QT Syndrome / diagnosis
  • Maternal Exposure / adverse effects*
  • Paroxetine / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Prenatal Exposure Delayed Effects / diagnosis
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Severity of Illness Index

Substances

  • Serotonin Uptake Inhibitors
  • Paroxetine