Blood Albumin as a Prognostic Factor Among Unselected Medically Treated Inpatients

Biomark Med. 2019 Sep;13(13):1059-1069. doi: 10.2217/bmm-2018-0465. Epub 2019 Sep 2.


Aim: The aim of this study is to determine the prognostic value of blood albumin (BA) in an unselected population of inpatients. Materials & methods: We performed prospective analysis of the medical documentation of 7279 patients hospitalized between July 2014 and September 2017. Results: Individuals with BA ≥3.35 mg/dl had significantly lower risk of in-hospital death (odds ratio [OR]: 0.22; 95% CI: 0.19-0.27; p < 0.001) and 14-day readmission (OR: 0.64; 95% CI: 0.55-0.77; p < 0.0001). BA concentration was the strongest favorable factor predicting inpatient survival in a Cox hazard regression model (OR: 0.43; 95% CI: 0.36-0.50; p < 0.001), did not correlate with body mass index and actual-to-ideal bodyweight ratio and was strongly affected by numerous non-nutrient factors. Conclusion: BA concentration showed similar or better predictive and diagnostic power in relation to all-cause in-hospital mortality and 14-day readmission among inpatients than selected multifactorial scores.

Keywords: biomarker; blood albumin; geriatric nutritional risk index; in-hospital death; inflammatory response; inpatients; nutritional risk assessment; nutritional status; prognosis; readmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Body Mass Index
  • Female
  • Hospital Mortality
  • Humans
  • Hypoalbuminemia / mortality
  • Hypoalbuminemia / pathology*
  • Male
  • Middle Aged
  • Odds Ratio
  • Patient Readmission
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • ROC Curve
  • Risk Factors
  • Serum Albumin / analysis*


  • Serum Albumin