Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study

J Alzheimers Dis. 2019;71(3):1063-1069. doi: 10.3233/JAD-190644.


Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n = 37) and TwX (n = 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.

Keywords: Dementia; dietary supplement; mild cognitive impairment; oxidative stress; randomized controlled trial.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / therapeutic use*
  • Cognition
  • Cognitive Dysfunction / drug therapy*
  • Cognitive Dysfunction / psychology
  • Cystine / therapeutic use*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Glutamine / therapeutic use*
  • Humans
  • Male
  • Mental Status and Dementia Tests
  • Prospective Studies
  • Treatment Outcome


  • Antioxidants
  • Twendee X
  • Glutamine
  • Cystine
  • Ascorbic Acid