Both "canonical" and "immunological" preeclampsia subtypes demonstrate changes in placental immune cell composition

Placenta. 2019 Aug:83:53-56. doi: 10.1016/j.placenta.2019.06.384. Epub 2019 Jun 27.

Abstract

Our prior work investigating the heterogeneity of preeclampsia identified multiple placental subtypes of this disorder, including a "canonical" group with maternal vascular malperfusion and an "immunological" group with signs of allograft rejection. Here, we perform a pilot immunohistochemistry study to investigate if an increase in infiltrating maternal immune cells is contributing to the "immunological" pathology subtype. This revealed an enrichment of monocytes and/or neutrophils (CD68 + and MPO+ cells) in the intervillous space of these placentas. Surprisingly, "canonical" samples also demonstrated a significant result, with decreased CD68 staining. As such, further immunohistochemistry to assess immune contributions in preeclampsia subtypes is warranted.

Keywords: Immune cells; Immunohistochemistry; Placenta; Preeclampsia; Subtypes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • CD68 Molecule
  • Epigenesis, Genetic
  • Female
  • Humans
  • Immunohistochemistry
  • Monocytes / immunology
  • Monocytes / pathology
  • Neutrophils / enzymology
  • Neutrophils / immunology
  • Neutrophils / pathology
  • Peroxidase / metabolism
  • Pilot Projects
  • Placenta / immunology*
  • Placenta / pathology
  • Pre-Eclampsia / classification
  • Pre-Eclampsia / immunology*
  • Pre-Eclampsia / pathology
  • Pregnancy

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Peroxidase
  • CD68 antigen, human
  • CD68 Molecule
  • MPO protein, human

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