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Review
. 2019 Sep 2;146(17):dev177188.
doi: 10.1242/dev.177188.

Inner Ear Organoids: New Tools to Understand Neurosensory Cell Development, Degeneration and Regeneration

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Free PMC article
Review

Inner Ear Organoids: New Tools to Understand Neurosensory Cell Development, Degeneration and Regeneration

Marta Roccio et al. Development. .
Free PMC article

Abstract

The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.

Keywords: Hair cells; Inner ear; Organoids; Regeneration; Stem cells.

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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