Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population-based cohort study

Dah-Ching Ding; Fung-Chang Sung; Weishan Chen; Jen-Hung Wang; Shinn-Zong Lin

doi:10.1111/tbj.13519

Proton pump inhibitors reduce breast cancer risk in gastric ulcer patients: A population-based cohort study

Breast J. 2020 Mar;26(3):474-478. doi: 10.1111/tbj.13519. Epub 2019 Sep 2.

Authors

Dah-Ching Ding^{1

2}, Fung-Chang Sung^{3

4}, Weishan Chen³, Jen-Hung Wang⁵, Shinn-Zong Lin⁶

Affiliations

¹ Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan.
² Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
³ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
⁴ Department of Health Services Administration, China Medical University Hospital, Taichung, Taiwan.
⁵ Department of Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan.
⁶ Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan.

PMID: 31478297
DOI: 10.1111/tbj.13519

Abstract

We aim to evaluate breast cancer risk relating to PPIs usage in women with peptic ulcer. From 2000 to 2013, incidence rates of breast cancer were compared between the two cohorts (with or without PPIs). Each study cohort consisted of 4838 women. The incidence density rate of breast cancer in the PPI cohort was 0.29 that in the comparison cohort (10.0 vs 31.6 per 10 000 person-years), with an adjusted HR (hazard ratio) of 0.32 (95% CI = 0.20-0.49) for the PPI cohort. In conclusion, the medication of PPIs is associated with reduced breast cancer risk for women with gastric ulcer.

Keywords: breast cancer; cohort study; gastric ulcer; proton pump inhibitors; retrospective.

MeSH terms

Breast Neoplasms* / epidemiology
Cohort Studies
Female
Humans
Incidence
Proton Pump Inhibitors / adverse effects
Stomach Ulcer* / chemically induced
Stomach Ulcer* / epidemiology

Substances

Proton Pump Inhibitors