Malignant phyllodes tumors of the breast: A comprehensive literature review

Breast J. 2020 Feb;26(2):240-244. doi: 10.1111/tbj.13523. Epub 2019 Sep 3.

Abstract

Malignant phyllodes tumors (MPT) have always been a great deal of controversy among fibroepithelial tumors of the breast. Genetics, histopathology, and tumor behavior on the cellular scale shape their extent of aggressiveness. Diagnosis is based on radiological and pathological findings. Cure is surgical excision. This article reveals the most common clinical indices, which should raise the surgeon's concerns on a benign-looking tumor to further investigate its nature, and the importance of an adequate surgical intervention, preferably done by an oncoplastic breast surgeon, in order to accomplish the ideal outcome for the patient.

Keywords: breast cancer; breast surgery; malignant phyllodes tumors of the breast.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Mammography
  • Mastectomy, Segmental*
  • Mediator Complex / genetics
  • Phyllodes Tumor / diagnostic imaging
  • Phyllodes Tumor / genetics
  • Phyllodes Tumor / pathology
  • Phyllodes Tumor / therapy*
  • Radiotherapy, Adjuvant
  • Telomerase / genetics
  • Ultrasonography, Mammary

Substances

  • Antineoplastic Agents
  • MED12 protein, human
  • Mediator Complex
  • TERT protein, human
  • Telomerase