The plant hormone kinetin in disease therapy and healthy aging

Ageing Res Rev. 2019 Nov;55:100958. doi: 10.1016/j.arr.2019.100958. Epub 2019 Aug 31.


It has been more than 60 years since the discovery of kinetin, the first known member of a group of plant hormones called cytokinins. In this review we summarize the health-promoting activity of kinetin in animal systems, ranging from cells cultured in vitro through invertebrates to mammals. Kinetin has been shown to modulate aging, to delay age-related physiological decline and to protect against some neurodegenerative diseases. We also review studies on its mechanism of action, as well as point out gaps in our current knowledge.

Keywords: Age-related diseases; Aging; Cytokinin; Kinetin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging*
  • Animals
  • Cytokinins
  • Healthy Aging*
  • Humans
  • Kinetin / pharmacology
  • Kinetin / therapeutic use*


  • Cytokinins
  • Kinetin