Nxf3: a middleman with the right connections for unspliced piRNA precursor export

Genes Dev. 2019 Sep 1;33(17-18):1095-1097. doi: 10.1101/gad.330530.119.


RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208-1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites.

Keywords: PIWI proteins; RNA export; nuclear export factor; piRNA clusters; transposon control.

Publication types

  • Review
  • Comment

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • DNA Transposable Elements
  • Drosophila / genetics
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • RNA, Small Interfering


  • DNA Transposable Elements
  • Drosophila Proteins
  • RNA, Small Interfering