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Review
. 2019 Sep 1;33(17-18):1095-1097.
doi: 10.1101/gad.330530.119.

Nxf3: A Middleman With the Right Connections for Unspliced piRNA Precursor Export

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Free PMC article
Review

Nxf3: A Middleman With the Right Connections for Unspliced piRNA Precursor Export

Mateusz Mendel et al. Genes Dev. .
Free PMC article

Abstract

RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208-1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites.

Keywords: PIWI proteins; RNA export; nuclear export factor; piRNA clusters; transposon control.

Figures

Figure 1.
Figure 1.
Canonical RNA Pol II transcripts originating from euchromatic loci (H3K4me3) are exported via the Nxf1 export receptor. Noncanonical Piwi-interacting RNA (piRNA) precursors from the dual-strand piRNA clusters that are located in heterochromatin (H3K9me3) use the germline-specific adaptor Nxf3 and the Crm1 (chromosomal maintenance 1)-dependent export pathway.

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