The cell cycle in stem cell proliferation, pluripotency and differentiation

Nat Cell Biol. 2019 Sep;21(9):1060-1067. doi: 10.1038/s41556-019-0384-4. Epub 2019 Sep 2.


Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology*
  • Cell Proliferation / physiology
  • Embryonic Stem Cells / cytology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / cytology*