Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes

J Neurophysiol. 2019 Dec 1;122(6):2203-2205. doi: 10.1152/jn.00089.2019. Epub 2019 Sep 4.

Abstract

The type of neuronal activity determines the outcome of gene expression. Hence, the characterization of underlying mechanisms in transcriptome alterations may serve as a biomarker and provide new intervention methods for the treatment of pathologic conditions. Parrish et al. (Parrish RR, Codadu NK, Racca C, Trevelyan AJ. J Neurophysiol 120: 2358-2367, 2018) show that the changes in interneuronal gene transcription are correlated with the type of the activated neuronal population and that the initiation route of Ras/ERK MAPK pathway determines the polarity of the gene expression.

Keywords: 0 Mg2+; 4AP; Gad1; Pvalb; activity-dependent gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Interneurons*
  • Neurons
  • Pyramidal Cells*
  • Transcription, Genetic