Pallidal low-frequency activity in dystonia after cessation of long-term deep brain stimulation

Mov Disord. 2019 Nov;34(11):1734-1739. doi: 10.1002/mds.27838. Epub 2019 Sep 4.


Objective: This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months.

Methods: Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz).

Results: A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints.

Conclusion: Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 International Parkinson and Movement Disorder Society.

Keywords: basal ganglia; deep brain stimulation; dystonia; globus pallidus; local field potentials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain*
  • Deep Brain Stimulation*
  • Dystonia / physiopathology
  • Dystonia / therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Movement Disorders / physiopathology
  • Movement Disorders / therapy*
  • Severity of Illness Index
  • Time
  • Treatment Outcome