Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum

Nutrients. 2019 Sep 3;11(9):2079. doi: 10.3390/nu11092079.


The metabolism of dietary polyphenols ellagitannins by the gut-microbiota allows the human stratification in urolithin metabotypes depending on the final urolithins produced. Metabotype-A only produces urolithin-A, metabotype-B yields urolithin-B and isourolithin-A in addition to urolithin-A, and metabotype 0 does not produce urolithins. Metabotype-A has been suggested to be 'protective', and metabotype-B dysbiotic-prone to cardiometabolic impairments. We analyzed the gut-microbiome of 40 healthy women and determined their metabotypes and enterotypes, and their associations with anthropometric and gut-microbial changes after 3 weeks, 4, 6, and 12 months postpartum. Metabotype-A was predominant in mothers who lost weight (≥2 kg) (75%) versus metabotype-B (54%). After delivery, the microbiota of metabotype-A mothers changed, unlike metabotype-B, which barely changed over 1 year. The metabotype-A discriminating bacteria correlated to the decrease of the women's waist while some metabotype-B bacteria were inversely associated with a reduction of body mass index (BMI), waist, and waist-to-hip ratio. Metabotype-B was associated with a more robust and less modulating microbial and anthropometric profiles versus metabotype-A, in which these profiles were normalized through the 1-year follow-up postpartum. Consequently, urolithin metabotypes assessment could be a tool to anticipate the predisposition of women to normalize their anthropometric values and gut-microbiota, significantly altered during pregnancy and after childbirth.

Keywords: body mass index; ellagitannins; gut dysbiosis; gut microbiome; lactation; polyphenols; postpartum.

MeSH terms

  • Adult
  • Anthropometry
  • Coumarins / metabolism*
  • Female
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Hydrolyzable Tannins / metabolism
  • Postpartum Period*
  • Time Factors


  • Coumarins
  • Hydrolyzable Tannins
  • isourolithin A
  • urolithin B
  • 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one