MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents

doi:10.1007/s00062-019-00834-9

. 2020 Dec;30(4):671-677.

doi: 10.1007/s00062-019-00834-9. Epub 2019 Sep 5.

MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents

Barbara Hofstadler¹, Philipp Bäumer^{1

2}, Daniel Schwarz¹, Moritz Kronlage¹, Sabine Heiland¹, Martin Bendszus¹, Tim Godel³

Affiliations

¹ Department of Neuroradiology, Neurological University Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
² Center for Radiology dia.log, Vinzenz-von-Paul Str. 8, 84503, Altötting, Germany.
³ Department of Neuroradiology, Neurological University Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. tim.godel@med.uni-heidelberg.de.

PMID: 31486885
DOI: 10.1007/s00062-019-00834-9

MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents

Barbara Hofstadler et al. Clin Neuroradiol. 2020 Dec.

. 2020 Dec;30(4):671-677.

doi: 10.1007/s00062-019-00834-9. Epub 2019 Sep 5.

Authors

Barbara Hofstadler¹, Philipp Bäumer^{1

2}, Daniel Schwarz¹, Moritz Kronlage¹, Sabine Heiland¹, Martin Bendszus¹, Tim Godel³

Affiliations

¹ Department of Neuroradiology, Neurological University Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
² Center for Radiology dia.log, Vinzenz-von-Paul Str. 8, 84503, Altötting, Germany.
³ Department of Neuroradiology, Neurological University Clinic, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. tim.godel@med.uni-heidelberg.de.

PMID: 31486885
DOI: 10.1007/s00062-019-00834-9

Abstract

Purpose: To determine normative morphological and functional magnetic resonance (MR) neurography values in children and adolescents in correlation to demographic determinants.

Methods: In this study 29 healthy underage subjects (mean age 13.9 years, range 10-17 years) were examined using a standardized MR neurography protocol of the lumbosacral plexus and the right lower extremity at 3 T. Volumes of the dorsal root ganglia L3-S2, cross-sectional area of the sciatic and tibial nerves, as well as T2-weighted contrast nerve-muscle ratio and quantitative diffusion tensor imaging (DTI) values of the sciatic nerve were obtained and correlated with the demographic parameters sex, age, height and weight.

Results: While all obtained morphological and functional MR neurography values did not differ between male and female sex, dorsal root ganglia volume, sciatic and tibial nerve cross-sectional area correlated positively with age, height, and weight. The T2-weighted signal of the sciatic nerve was independent of demographic determinants. Negative correlation was found for fractional anisotropy (FA) with age, height, and weight, whereas radial diffusivity (RD) showed a positive correlation only with age. Mean diffusivity (MD) and axial diffusivity (AD) revealed no correlation with demographic determinants.

Conclusion: The results of this study suggest that selection of sex-matched controls for further studies assessing peripheral nerve pathologies in underage patients may not be necessary; however, control subjects should be adapted to age, height, and weight of the patient population, especially if assessing dorsal root ganglia volume, nerve cross-sectional area and DTI.

Keywords: Demographic determinants; Dorsal root ganglia; Magnetic resonance neurography; Peripheral nerves; Underage normative values.

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References

1. Godel T, Bäumer P, Farschtschi S, Gugel I, Kronlage M, Hofstadler B, Heiland S, Gelderblom M, Bendszus M, Mautner VF. Peripheral nervous system alterations in infant and adult neurofibromatosis type 2. Neurology. 2019;93:e590–8. - DOI
1. Godel T, Bäumer P, Pham M, Köhn A, Muschol N, Kronlage M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Human dorsal root ganglion in vivo morphometry and perfusion in Fabry painful neuropathy. Neurology. 2017;89:1274–82. - DOI
1. Godel T, Bäumer P, Stumpfe K, Muschol N, Kronlage M, Brunnée M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Dorsal root ganglia volume is increased in patients with the Fabry-related GLA variant p.D313Y. J Neurol. 2019;266:1332-9. - DOI
1. Godel T, Köhn A, Muschol N, Kronlage M, Schwarz D, Kollmer J, Heiland S, Bendszus M, Mautner VF, Bäumer P. Dorsal root ganglia in vivo morphometry and perfusion in female patients with Fabry disease. J Neurol. 2018;265:2723-9. - DOI
1. Godel T, Mautner VF, Farschtschi S, Pham M, Schwarz D, Kronlage M, Gugel I, Heiland S, Bendszus M, Bäumer P. Dorsal root ganglia volume differentiates schwannomatosis and neurofibromatosis 2. Ann Neurol. 2018;83:854–7. - DOI

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[1] Godel T, Bäumer P, Farschtschi S, Gugel I, Kronlage M, Hofstadler B, Heiland S, Gelderblom M, Bendszus M, Mautner VF. Peripheral nervous system alterations in infant and adult neurofibromatosis type 2. Neurology. 2019;93:e590–8. - DOI

[2] Godel T, Bäumer P, Farschtschi S, Gugel I, Kronlage M, Hofstadler B, Heiland S, Gelderblom M, Bendszus M, Mautner VF. Peripheral nervous system alterations in infant and adult neurofibromatosis type 2. Neurology. 2019;93:e590–8. - DOI

[3] Godel T, Bäumer P, Pham M, Köhn A, Muschol N, Kronlage M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Human dorsal root ganglion in vivo morphometry and perfusion in Fabry painful neuropathy. Neurology. 2017;89:1274–82. - DOI

[4] Godel T, Bäumer P, Pham M, Köhn A, Muschol N, Kronlage M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Human dorsal root ganglion in vivo morphometry and perfusion in Fabry painful neuropathy. Neurology. 2017;89:1274–82. - DOI

[5] Godel T, Bäumer P, Stumpfe K, Muschol N, Kronlage M, Brunnée M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Dorsal root ganglia volume is increased in patients with the Fabry-related GLA variant p.D313Y. J Neurol. 2019;266:1332-9. - DOI

[6] Godel T, Bäumer P, Stumpfe K, Muschol N, Kronlage M, Brunnée M, Kollmer J, Heiland S, Bendszus M, Mautner VF. Dorsal root ganglia volume is increased in patients with the Fabry-related GLA variant p.D313Y. J Neurol. 2019;266:1332-9. - DOI

[7] Godel T, Köhn A, Muschol N, Kronlage M, Schwarz D, Kollmer J, Heiland S, Bendszus M, Mautner VF, Bäumer P. Dorsal root ganglia in vivo morphometry and perfusion in female patients with Fabry disease. J Neurol. 2018;265:2723-9. - DOI

[8] Godel T, Köhn A, Muschol N, Kronlage M, Schwarz D, Kollmer J, Heiland S, Bendszus M, Mautner VF, Bäumer P. Dorsal root ganglia in vivo morphometry and perfusion in female patients with Fabry disease. J Neurol. 2018;265:2723-9. - DOI

[9] Godel T, Mautner VF, Farschtschi S, Pham M, Schwarz D, Kronlage M, Gugel I, Heiland S, Bendszus M, Bäumer P. Dorsal root ganglia volume differentiates schwannomatosis and neurofibromatosis 2. Ann Neurol. 2018;83:854–7. - DOI

[10] Godel T, Mautner VF, Farschtschi S, Pham M, Schwarz D, Kronlage M, Gugel I, Heiland S, Bendszus M, Bäumer P. Dorsal root ganglia volume differentiates schwannomatosis and neurofibromatosis 2. Ann Neurol. 2018;83:854–7. - DOI

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MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents

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MR Neurography: Normative Values in Correlation to Demographic Determinants in Children and Adolescents

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