Cornusglucosides A and B, Two New Iridoid Glucosides from the Fruit of Cornus officinalis

Chem Biodivers. 2019 Nov;16(11):e1900421. doi: 10.1002/cbdv.201900421. Epub 2019 Sep 30.

Abstract

Phytochemical study on the fruit of Cornus officinalis Sieb. et Zucc. yielded two new iridoid glucosides, named cornusglucoside A (1) and cornusglucoside B (2). The structures of 1 and 2 were elucidated via comprehensive NMR and HR-ESI-MS data analysis. Additionally, their inhibitory effects on IL-6-induced STAT3 activation were assessed.

Keywords: Cornus officinalis; IL-6/STAT3; biological activity; cornusglucosides A and B; iridoid glucoside; phytochemistry.

MeSH terms

  • Cornus / chemistry*
  • Fruit / chemistry*
  • Hep G2 Cells
  • Humans
  • Interleukin-6 / antagonists & inhibitors
  • Interleukin-6 / metabolism
  • Iridoid Glucosides / chemistry
  • Iridoid Glucosides / isolation & purification*
  • Iridoid Glucosides / pharmacology
  • Molecular Conformation
  • STAT3 Transcription Factor / antagonists & inhibitors
  • STAT3 Transcription Factor / metabolism

Substances

  • Interleukin-6
  • Iridoid Glucosides
  • STAT3 Transcription Factor
  • STAT3 protein, human