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Review
, 20 (18)

The Role of Exosomes in Pancreatic Cancer

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Review

The Role of Exosomes in Pancreatic Cancer

Bin Lan et al. Int J Mol Sci.

Abstract

Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are membrane vesicles which are important in the progression, metastasis and chemoresistance in pancreatic cancer. Additionally, they have been verified to be potential as biomarkers, targets and drug carriers for pancreatic cancer treatment. Thus, studying the role of exosomes in pancreatic cancer is significant. This paper focuses on the role of exosomes in the proliferation, metastasis and chemoresistance, as well as their potential applications for pancreatic cancer.

Keywords: biomarker; chemoresistance; exosomes; pancreatic cancer.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Exosomes biological features. Exosomes are vesicles of endocytic origin. After the plasma membrane sprouts inward to form the early endosomes, the multivesicular bodies (MVBs) further sprouts inward to produce intraluminal vesicles (ILVs), MVBs fuse with the plasma membrane, releasing exosomes into the extracellular space. Exosomes are mainly consisted by proteins, lipids and nucleic acids. Nucleic acids include microRNA (miRNA), transfer RNA (tRNA), ribosomalRNA (rRNA), messenger RNA (mRNA), and non-coding RNA (ncRNA). Exosomes also contain endosome-specific tetraspanins (CD9, CD63, CD81) on their membrane surfaces. major histocompatibility complex, MHC; UL16 binding protein, ULBP; hot shock protein, hsp; ras-related gtp-binding protein, Rab; endosomal sorting complex required for the transport, ESCRT.

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