Protective activity of mogroside V against ovalbumin-induced experimental allergic asthma in Kunming mice

J Food Biochem. 2019 Sep;43(9):e12973. doi: 10.1111/jfbc.12973. Epub 2019 Jul 24.


We investigated the antiasthmatic effect of mogroside V (Mog V) in mice with ovalbumin (OVA)-induced asthma. Administration of Mog V effectively attenuated OVA-induced airway hyperresponsiveness and reduced the number of inflammatory cells in bronchoalveolar lavage fluid (BALF). Histological examination showed that Mog V reduced the inflammatory infiltration of the lungs in the asthmatic mice. ELISAs suggested that Mog V effectively decreased the levels of IL-4, IL-5, and IL-13 in BALF and serum levels of OVA-specific IgE and IgG1 in the asthmatic mice. A quantitative reverse-transcription PCR assay also indicated that Mog V decreased the mRNA levels of IL-17A, IL-23, and RORγt in the lungs of the asthmatic mice (the opposite effect on Foxp3 mRNA). Furthermore, Mog V significantly reduced the OVA-induced activation of NF-κB in the lungs. This study indicates that Mog V alleviates OVA-induced inflammation in airways, and this effect is associated with a reduction in NF-κB activation. PRACTICAL APPLICATIONS: A traditional Chinese medicine herb has been reported to have a strong curative effect on asthma in clinical practice. Siraitia grosvenorii is known in China as a functional food product with the ability to improve lung function. Mogroside V is a triterpene glycoside isolated from S. grosvenorii. Nonetheless, the antiasthmatic effect of mogroside V has not been evaluated yet. The aim of this study was to investigate the antiasthmatic activity of mogroside V in mice with chemically induced asthma. The data from this study will provide some scientific evidence supporting wider use of S. grosvenorii in functional foods.

Keywords: Kunming mice; Mogroside V; OVA; asthma; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asthma / chemically induced*
  • Asthma / drug therapy*
  • Bronchoalveolar Lavage Fluid / cytology
  • Cytokines / metabolism
  • Eosinophils / drug effects
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / immunology
  • Lymphocytes / drug effects
  • Macrophages / drug effects
  • Male
  • Mice
  • Molecular Structure
  • Neutrophils / drug effects
  • Ovalbumin / toxicity*
  • Random Allocation
  • Triterpenes / chemistry
  • Triterpenes / therapeutic use*


  • Cytokines
  • Triterpenes
  • mogroside V
  • Ovalbumin