Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones

J Agric Food Chem. 2019 Sep 25;67(38):10553-10562. doi: 10.1021/acs.jafc.9b03602. Epub 2019 Sep 16.


Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and detected frequently in fruits, vegetables, as well as in urine and blood in humans. Studies have suggested that CPF can induce metabolic disruption, such as type-2 diabetes mellitus and changed body weight. The main mechanisms are based on oxidative damage, fatty-acid synthesis, and lipid peroxidation. Studies have also shown that CPF can change reproductive hormone (RH) levels. CPF might result in metabolic disorders through altered RH levels. Here, we review the studies showing that CFP causes metabolic disruption. Then, we present the studies showing that CFP changes RH levels. Finally, we discuss a potential pathway of how CPF elicits metabolic disruption.

Keywords: T2DM; chlorpyrifos; gonadotropins; obesity; sex hormones.

Publication types

  • Review

MeSH terms

  • Animals
  • Chlorpyrifos / toxicity*
  • Gonadal Hormones / metabolism*
  • Humans
  • Insecticides / toxicity*
  • Lipid Peroxidation
  • Metabolic Diseases / etiology
  • Metabolic Diseases / metabolism*


  • Gonadal Hormones
  • Insecticides
  • Chlorpyrifos