The Face of Chromatin Variants

Cell. 2019 Sep 5;178(6):1284-1286. doi: 10.1016/j.cell.2019.08.024.


A developmental program affecting human face shape is shown by Greenberg et al. (2019) to hinge on the ability to distinguish a single methyl group between two histone variant isoforms and the action of the chromatin-remodeling enzyme SRCAP. This challenges researchers to link atomic structure to a morphological defect.

Publication types

  • Comment

MeSH terms

  • Amino Acids
  • Chromatin Assembly and Disassembly
  • Chromatin*
  • Histones*
  • Humans
  • Protein Isoforms


  • Amino Acids
  • Chromatin
  • Histones
  • Protein Isoforms