The RAC2-PI3K axis regulates human NK cell maturation and function

Clin Immunol. 2019 Nov:208:108257. doi: 10.1016/j.clim.2019.108257. Epub 2019 Sep 3.

Authors

Giovanna Tabellini¹, Manuela Baronio², Ornella Patrizi¹, Alessio Benevenuto², Luisa Gazzurelli², Alessandro Plebani², Silvia Parolini¹, Vassilios Lougaris³

Affiliations

¹ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
² Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili di Brescia, Italy.
³ Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia and ASST-Spedali Civili di Brescia, Italy. Electronic address: vlougarisbs@yahoo.com.

PMID: 31491520
DOI: 10.1016/j.clim.2019.108257

No abstract available

Keywords: Cytotoxicity; NK cells; PI3K; RAC2; p110d.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation / immunology
Cells, Cultured
Cytotoxicity, Immunologic / immunology*
Humans
Immunologic Deficiency Syndromes / genetics
Immunologic Deficiency Syndromes / immunology*
Killer Cells, Natural / immunology*
Lymphocyte Activation / immunology
Phosphatidylinositol 3-Kinases / genetics
Phosphatidylinositol 3-Kinases / immunology
RAC2 GTP-Binding Protein
Signal Transduction / immunology
rac GTP-Binding Proteins / genetics
rac GTP-Binding Proteins / immunology*

Substances

rac GTP-Binding Proteins