Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

Brain Behav Immun. 2019 Nov;82:309-318. doi: 10.1016/j.bbi.2019.09.001. Epub 2019 Sep 4.


An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.

Keywords: Gut microbiome; High fat diet feeding; Minocycline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anxiety / metabolism
  • Behavior, Animal / physiology
  • Depression / metabolism
  • Depressive Disorder, Major / metabolism
  • Diet, High-Fat / adverse effects
  • Disease Models, Animal
  • Gastrointestinal Microbiome / drug effects*
  • Gastrointestinal Microbiome / physiology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microbiota / drug effects
  • Minocycline / metabolism
  • Minocycline / pharmacology*


  • Minocycline