A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model

Neuroimage. 2019 Dec;203:116163. doi: 10.1016/j.neuroimage.2019.116163. Epub 2019 Sep 5.

Abstract

Purpose: Positron emission tomography (PET) is a non-invasive imaging tool for the evaluation of brain function and neuronal activity in normal and diseased conditions with high sensitivity. The macaque monkey serves as a valuable model system in the field of translational medicine, for its phylogenetic proximity to man. To translation of non-human primate neuro-PET studies, an effective and objective data analysis platform for neuro-PET studies is needed.

Materials and methods: A set of stereotaxic templates of macaque brain, namely the Institute of High Energy Physics & Jinan University Macaque Template (HJT), was constructed by iteratively registration and averaging, based on 30 healthy rhesus monkeys. A brain atlas image was created in HJT space by combining sub-anatomical regions and defining new 88 bilateral functional regions, in which a unique integer was assigned for each sub-anatomical region.

Results: The HJT comprised a structural MRI T1 weighted image (T1WI) template image, a functional FDG-PET template image, intracranial tissue segmentations accompanied with a digital macaque brain atlas image. It is compatible with various commercially available software tools, such as SPM and PMOD. Data analysis was performed on a stroke model compared with a group of healthy controls to demonstrate the usage of HJT.

Conclusion: We have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.

Keywords: Brain; Ischemia; MRI; Macaque; PET; Positron emission tomography; Template.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atlases as Topic
  • Brain / anatomy & histology
  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Brain / pathology
  • Brain Ischemia / diagnostic imaging*
  • Brain Ischemia / metabolism
  • Brain Ischemia / pathology
  • Brain Mapping / methods*
  • Female
  • Image Processing, Computer-Assisted / methods*
  • Macaca fascicularis
  • Macaca mulatta
  • Magnetic Resonance Imaging*
  • Male
  • Positron-Emission Tomography*
  • Species Specificity