A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model

Binbin Nie; Lu Wang; Yichao Hu; Shengxiang Liang; Zhiqiang Tan; Pei Chai; Yongjin Tang; Jingjie Shang; Zhangsheng Pan; Xudong Zhao; Xiaofei Zhang; Jianxian Gong; Chao Zheng; Hao Xu; Hsiao-Ying Wey; Steven H Liang; Baoci Shan

doi:10.1016/j.neuroimage.2019.116163

A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model

Neuroimage. 2019 Dec:203:116163. doi: 10.1016/j.neuroimage.2019.116163. Epub 2019 Sep 5.

Authors

Binbin Nie¹, Lu Wang², Yichao Hu³, Shengxiang Liang¹, Zhiqiang Tan², Pei Chai¹, Yongjin Tang², Jingjie Shang², Zhangsheng Pan², Xudong Zhao⁴, Xiaofei Zhang⁵, Jianxian Gong⁶, Chao Zheng⁷, Hao Xu⁸, Hsiao-Ying Wey⁷, Steven H Liang⁵, Baoci Shan⁹

Affiliations

¹ Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
² Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China.
³ College of Information Engineering, Xiangtan University, Xiangtan, 411105, China.
⁴ Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
⁵ Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, 02114, USA.
⁶ State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
⁷ Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
⁸ Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China. Electronic address: txh@jnu.edu.cn.
⁹ Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China; Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging, Jinan University, Guangzhou, 510630, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China. Electronic address: shanbc@ihep.ac.cn.

PMID: 31494249
DOI: 10.1016/j.neuroimage.2019.116163

Abstract

Purpose: Positron emission tomography (PET) is a non-invasive imaging tool for the evaluation of brain function and neuronal activity in normal and diseased conditions with high sensitivity. The macaque monkey serves as a valuable model system in the field of translational medicine, for its phylogenetic proximity to man. To translation of non-human primate neuro-PET studies, an effective and objective data analysis platform for neuro-PET studies is needed.

Materials and methods: A set of stereotaxic templates of macaque brain, namely the Institute of High Energy Physics & Jinan University Macaque Template (HJT), was constructed by iteratively registration and averaging, based on 30 healthy rhesus monkeys. A brain atlas image was created in HJT space by combining sub-anatomical regions and defining new 88 bilateral functional regions, in which a unique integer was assigned for each sub-anatomical region.

Results: The HJT comprised a structural MRI T1 weighted image (T1WI) template image, a functional FDG-PET template image, intracranial tissue segmentations accompanied with a digital macaque brain atlas image. It is compatible with various commercially available software tools, such as SPM and PMOD. Data analysis was performed on a stroke model compared with a group of healthy controls to demonstrate the usage of HJT.

Conclusion: We have constructed a stereotaxic template set of macaque brain named HJT, which standardizes macaque neuroimaging data analysis, supports novel radiotracer development and facilitates translational neuro-disorders research.

Keywords: Brain; Ischemia; MRI; Macaque; PET; Positron emission tomography; Template.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atlases as Topic
Brain / anatomy & histology
Brain / diagnostic imaging*
Brain / metabolism
Brain / pathology
Brain Ischemia / diagnostic imaging*
Brain Ischemia / metabolism
Brain Ischemia / pathology
Brain Mapping / methods*
Female
Image Processing, Computer-Assisted / methods*
Macaca fascicularis
Macaca mulatta
Magnetic Resonance Imaging*
Male
Positron-Emission Tomography*
Species Specificity