Microglia in Memory Decline from Zika Virus and West Nile Virus Infection

Trends Neurosci. 2019 Nov;42(11):757-759. doi: 10.1016/j.tins.2019.08.009. Epub 2019 Sep 5.


Neurotropic viral infection can result in complications underscored by persistent T cell presence in the brain linked with cognitive decline. A recent study by Garber et al. showed that sustained T cell production of interferon (IFN)-γ mediating microglia activation triggers cognitive decline during recovery from Zika virus (ZIKV) or West Nile virus (WNV) infection.

Keywords: flavivirus; memory; microglia.

Publication types

  • Comment

MeSH terms

  • Cognitive Dysfunction*
  • Flavivirus*
  • Humans
  • Memory Disorders
  • Microglia
  • T-Lymphocytes
  • West Nile Fever*
  • West Nile virus*
  • Zika Virus Infection*
  • Zika Virus*