Background: A diagnostic indicator for differentiating squamous cell carcinomas (SCCs) from inverted papillomas (IPs) has not been established. Objectives: This study aimed to evaluate whether CT attenuation values relative to those of the brainstem (relative CT number) could be useful in differentiating IPs from SCCs. Material and Methods: Consecutive patients who were pathologically diagnosed with IP or SCC between 2007 and 2017 were retrospectively identified. Relative CT numbers were compared between the two patient groups. The factors with predictive power for differentiating IPs from SCCs were identified by univariate and multivariate logistic regression analyses. Results: Fifty-four sinonasal tumour cases were finally analysed (IP, 25 cases; SCC, 29 cases). Relative CT numbers were significantly higher in SCC than in IP (p < .001). The univariate logistic regression analysis showed BMI, relative CT number, and disease duration to have predictive value for differentiating IPs from SCCs. In the multivariate logistic regression analysis, only the relative CT number had predictive value for distinguishing IP from SCC (odds ratio, 1.97), with a relative CT number of ≥1.4 being significantly associated with SCC. Conclusions: High relative CT numbers could potentially be used to identify SCCs, and their measurement could provide a basis for differentiating IPs from SCCs.
Keywords: Inverted papilloma; brainstem; computed tomography; diagnosis; squamous cell carcinoma.
Differentiation of Squamous Cell Carcinoma and Inverted Papilloma Using Non-Invasive MR Perfusion ImagingN Fujima et al. Dentomaxillofac Radiol 44 (9), 20150074. PMID 26054571.The pseudocontinuous arterial spin labelling technique can be a useful non-invasive diagnostic tool to differentiate SCC from IP in nasal or sinonasal cavity.
Imaging Predictors for Malignant Transformation of Inverted PapillomaCH Yan et al. Laryngoscope 129 (4), 777-782. PMID 30515841.Evaluation of CCP and DWI with ADC values on MRI are promising qualitative and quantitative methods to help differentiate benign IP tumors from their transformed malignan …
Survivin and Cortactin Expression in Sinonasal Schneiderian (Inverted) Papilloma and Associated CarcinomaG Marioni et al. Am J Rhinol Allergy 32 (2), 78-81. PMID 29644904.Nuclear survivin expression was significantly higher in SCCs than in IPs. Prospective, multi-institutional prognostic studies, preferably on an international scale (given …
Survival Outcomes of Squamous Cell Carcinoma Arising From Sinonasal Inverted Papilloma: Report of 6 Cases With Systematic Review and Pooled AnalysisT Tanvetyanon et al. Am J Otolaryngol 30 (1), 38-43. PMID 19027511. - ReviewAlthough the survival outcome of SCC arising from IP seems comparable with sinonasal SCCs, some patients with this disease do have a highly aggressive disease, including …
The Role of the Human Papillomavirus in the Pathogenesis of Schneiderian Inverted Papillomas: An Analytic Overview of the EvidenceW Lawson et al. Head Neck Pathol 2 (2), 49-59. PMID 20614323. - ReviewWe hypothesize that LR HPV may induce IP formation, and then are lost as infected cells are shed, as a "hit and run" phenomenon. HPV detection rates increase in dysplasti …