Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity

J Med Chem. 1979 Sep;22(9):1079-82. doi: 10.1021/jm00195a013.


A group of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides were synthesized to investigate the effects that changes in functionality on the terminal hydrazide nitrogen have on analgesic and antiinflammatory activities. The most active analgesic-antiinflammatory compound was 1-(2-pyridylcarbonyl)-2-(2-pyridyl)hydrazine (10a), which was much more potent than dextropropoxyphene and caused a 100% inhibition of carrageenan-induced paw edema up to 5 h. Pyridylcarbonylhydrazides 5a, 8, and 10c exhibited analgesic activity similar to dextropropoxyphene. Although 10b was an inactive analgesic agent, it exhibited antiinflammatory activity similar to 10a.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Female
  • Hydrazines / chemical synthesis*
  • Hydrazines / pharmacology
  • Male
  • Mice
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Rats
  • Structure-Activity Relationship


  • Anti-Inflammatory Agents, Non-Steroidal
  • Hydrazines
  • Pyridines