Abstract
Extracts of brewer's yeast have been fractionated, and the effects of fractions on the incorporation of 14C-labelled precursors into glycogen by hepatocytes have been studied. Purification of fractions which enhanced response to insulin resulted in the isolation of gamma-aminobutyric acid (GABA) which stimulated glycogen synthetase activity in the presence but not in the absence of suboptimal insulin concentrations.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cells, Cultured
-
Chemical Fractionation
-
Enzyme Activation
-
Fasting
-
Gluconeogenesis
-
Glycogen Synthase / metabolism*
-
Insulin / physiology*
-
Liver / cytology
-
Liver / metabolism*
-
Liver / physiology
-
Rats
-
Saccharomyces cerevisiae / analysis*
-
Scintillation Counting
-
Solubility
-
gamma-Aminobutyric Acid / physiology*
Substances
-
Insulin
-
gamma-Aminobutyric Acid
-
Glycogen Synthase