Extracts of brewer's yeast contain GABA which enhances activation of glycogen synthetase by insulin in isolated rat hepatocytes

Biochem Int. 1988 Dec;17(6):1107-16.

Abstract

Extracts of brewer's yeast have been fractionated, and the effects of fractions on the incorporation of 14C-labelled precursors into glycogen by hepatocytes have been studied. Purification of fractions which enhanced response to insulin resulted in the isolation of gamma-aminobutyric acid (GABA) which stimulated glycogen synthetase activity in the presence but not in the absence of suboptimal insulin concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Chemical Fractionation
  • Enzyme Activation
  • Fasting
  • Gluconeogenesis
  • Glycogen Synthase / metabolism*
  • Insulin / physiology*
  • Liver / cytology
  • Liver / metabolism*
  • Liver / physiology
  • Rats
  • Saccharomyces cerevisiae / analysis*
  • Scintillation Counting
  • Solubility
  • gamma-Aminobutyric Acid / physiology*

Substances

  • Insulin
  • gamma-Aminobutyric Acid
  • Glycogen Synthase