Serum lipids and risk of atherosclerosis in xanthelasma palpebrarum: A systematic review and meta-analysis

J Am Acad Dermatol. 2020 Mar;82(3):596-605. doi: 10.1016/j.jaad.2019.08.082. Epub 2019 Sep 6.

Abstract

Background: The association between dyslipidemia and xanthelasma palpebrarum (XP) remains controversial, and no definite evidence has indicated atherosclerosis risk in patients with XP.

Objective: The present study was a systematic review and meta-analysis to elucidate the association of serum lipid profiles and risk of atherosclerotic diseases with XP.

Methods: We systematically searched for the eligible comparative studies published before April 15, 2019, in the databases of PubMed, Web of Science, Embase, and Cochrane Library. A random-effects model was used to calculate the standard mean difference with 95% confidence interval for each pooled estimate.

Results: The qualitative analyses included 15 case-control studies with 854 patients with XP. Compared with the controls, the patients with XP had significantly higher serum levels of total cholesterol and low-density lipoproteins, significantly higher apolipoprotein B levels, and relatively lower apolipoprotein A1 levels, and the carotid intima-media thickness was significantly higher.

Conclusion: Patients with XP had significantly higher serum levels of atherogenic low-density lipoproteins and bore significantly higher risk of atherosclerosis than the controls. Careful monitoring and targeted intervention for prevention of cardiovascular diseases is essential for these patients.

Keywords: apolipoprotein; atherosclerosis; cholesterol; meta-analysis; serum lipids; xanthelasma palpebrarum.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Atherosclerosis / blood
  • Atherosclerosis / epidemiology*
  • Atherosclerosis / etiology
  • Atherosclerosis / prevention & control
  • Case-Control Studies
  • Eyelids / pathology*
  • Humans
  • Lipoproteins, LDL / blood*
  • Risk Factors
  • Xanthomatosis / blood
  • Xanthomatosis / complications*
  • Xanthomatosis / pathology

Substances

  • Lipoproteins, LDL