Myasthenia gravis and lymphoma. A clinical and immunological association

JAMA. 1979 Nov 9;242(19):2096-7.


Myasthenia gravis and lymphoma rarely coexist, but the occurrence of myasthenia shortly after the treatment of a patient with poorly differentiated nodular lymphoma suggested that an immunological disorder may have contributed to the development of both diseases; the fundamental defects in this association may be impaired immunological surveillance and impaired regulation of immune responses to autoantigens. The finding of T-cell immunodeificiency, including profound T-cell lymphopenia, impaired delayed hypersensitivity responses, and failure to a thymus-dependent antibody response to Salmonella adelaide flagellin, is consistent with this hypothesis.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / analysis
  • Autoantigens / immunology
  • Humans
  • Immunologic Surveillance
  • Lymphoma / complications
  • Lymphoma / immunology*
  • Lymphoma / radiotherapy
  • Lymphopenia / immunology
  • Male
  • Middle Aged
  • Muscle, Smooth / immunology
  • Myasthenia Gravis / etiology
  • Myasthenia Gravis / immunology*
  • Radiotherapy Dosage
  • T-Lymphocytes / immunology*


  • Autoantibodies
  • Autoantigens