Hydrothermal-assisted Synthesis of Highly Crystalline Titania-Copper Oxide Binary Systems With Enhanced Antibacterial Properties

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109839. doi: 10.1016/j.msec.2019.109839. Epub 2019 Jun 15.


Binary oxide systems containing TiO2 and CuO were synthesized using hydrothermal treatment and shown to have enhanced antibacterial properties. A detailed investigation was made of the effect of the molar ratio of components (TiO2:CuO = 7:3, 5:5, 3:7, 1:9) on the physicochemical parameters and antibacterial activity. Analysis of morphology (SEM, TEM and HRTEM) confirmed the presence of spherical and sheet-shaped particles. On the XRD patterns for the binary oxide materials, two crystalline forms (anatase and monoclinic CuO) were observed. It was found that an increase in CuO content led to a decrease in the BET surface area of the TiO2-CuO binary oxide systems. The synthesized TiO2-CuO materials exhibited very good antibacterial activity against both Gram-positive (methicillin-resistant Staphylococcus aureus and Bacillus cereus) and Gram-negative (Salmonella Enteritidis and Pseudomonas aeruginosa) bacteria. The obtained results show that TiO2-CuO oxide materials may have applications in the biomedical and food industries.

Keywords: Antibacterial activity; Copper oxide; Hydrothermal synthesis; TiO(2)-CuO binary oxide systems; Titania.

MeSH terms

  • Adsorption
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Copper / pharmacology*
  • Crystallization
  • Microbial Sensitivity Tests
  • Nitrogen / chemistry
  • Porosity
  • Spectroscopy, Fourier Transform Infrared
  • Surface Properties
  • Temperature*
  • Titanium / pharmacology*
  • Water / chemistry*
  • X-Ray Diffraction


  • Anti-Bacterial Agents
  • Water
  • titanium dioxide
  • Copper
  • Titanium
  • Nitrogen
  • cuprous oxide