Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov;104:109930.
doi: 10.1016/j.msec.2019.109930. Epub 2019 Jun 29.

Injectable Hydrogel Composed of Hydrophobically Modified Chitosan/Oxidized-Dextran for Wound Healing

Affiliations

Injectable Hydrogel Composed of Hydrophobically Modified Chitosan/Oxidized-Dextran for Wound Healing

Xinchen Du et al. Mater Sci Eng C Mater Biol Appl. .

Abstract

An injectable hydrogel dressing with multifunctional properties of superior hemostasis, antibacterial activity, tissue adhesive and cytocompatibility is desirable candidate in wound healing. In this study, we developed a novel hydrogel dressing composed of hydrophobically modified chitosan (hmCS) and oxidized dextran (OD). The gelation time, microstructure, injectability, self-healing and rheological properties were characterized. The in vitro ability of the precursor solution of the hydrogels to coagulate heparinized whole blood was confirmed. The in vivo hemostatic activity was demonstrated in a rat hemorrhaging liver model. The antibacterial activity against S. aureus and P. aeruginosa was evaluated in vitro through surface antibacterial test. The corresponding killing efficiencies were up to 95.0% and 96.4% at bacterial concentration of 108 CFU/mL. The cytotoxicity was examined by co-culturing with 3 T3 fibroblast cells. The wound healing functions were further verified with an infected wound model of rat skin. The aforementioned findings demonstrated that the hydrogel with multifunctional activities has potential for hemorrhagic and infected wound healing.

Keywords: Anti-bacteria; Hemostasis; Hydrogel dressing; Hydrophobically modified chitosan; Wound healing.

Similar articles

See all similar articles

MeSH terms

LinkOut - more resources

Feedback