Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma

Int J Mol Sci. 2019 Sep 8;20(18):4417. doi: 10.3390/ijms20184417.


Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led to the design, testing, and approval of several innovative agents that dramatically changed the treatment landscape for MCL patients. Most importantly, the implementation of new drugs and novel treatment algorithms into clinical practice has successfully translated into improved outcomes of MCL patients not only in the clinical trials, but also in real life. This review focuses on recent advances in our understanding of the pathogenesis of MCL, and provides a brief survey of currently used treatment options with special focus on mode of action of selected innovative anti-lymphoma molecules. Finally, it outlines future perspectives of patient management with progressive shift from generally applied immunotherapy toward risk-stratified, patient-tailored protocols that would implement innovative agents and/or procedures with the ultimate goal to eradicate the lymphoma and cure the patient.

Keywords: B-cell receptor signaling; cell cycle; mantle cell lymphoma.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Biomarkers, Tumor / antagonists & inhibitors*
  • Cell Cycle / drug effects
  • Cell Cycle / genetics
  • Clonal Evolution / drug effects
  • Clonal Evolution / genetics
  • Combined Modality Therapy
  • Disease Susceptibility
  • Drug Resistance, Neoplasm
  • Gene Expression Regulation, Neoplastic / drug effects
  • Genetic Variation
  • Humans
  • Lymphoma, Mantle-Cell / drug therapy*
  • Lymphoma, Mantle-Cell / etiology*
  • Lymphoma, Mantle-Cell / metabolism
  • Lymphoma, Mantle-Cell / mortality
  • Molecular Targeted Therapy* / methods
  • Prognosis
  • Receptors, Antigen, B-Cell / metabolism
  • Recurrence
  • Signal Transduction / drug effects
  • Treatment Outcome


  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Receptors, Antigen, B-Cell