Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization

Int J Stroke. 2019 Oct;14(8):818-825. doi: 10.1177/1747493019873706. Epub 2019 Sep 9.


An effective primary stroke prevention strategy on a global scale should integrate pharmacological (polypill) and lifestyle modifications (motivational population-wide strategy) interventions. Side effects of such an integrative approach are expected to be minimal and the benefits among individuals at low-to-moderate risk of stroke could be significant. In the future, pragmatic field trials will provide more evidence.

Keywords: Polypill; fixed-dose combination; primary prevention; stroke.

MeSH terms

  • Behavior Control
  • Community Health Workers*
  • Cost-Benefit Analysis
  • Dementia / economics
  • Dementia / prevention & control*
  • Healthy Lifestyle*
  • Humans
  • Motivation
  • Polypharmacy
  • Population Groups*
  • Risk Factors
  • Smartphone
  • Stroke / economics
  • Stroke / prevention & control*