Model of Moderate Hyperhomocisteinemia Associated with Mechanical Injury: Dynamics of Morphometric Parameters of Microcirculatory Vessels

Bull Exp Biol Med. 2019 Aug;167(4):533-535. doi: 10.1007/s10517-019-04567-0. Epub 2019 Sep 9.

Abstract

A model of moderate hyperhomocysteinemia associated with mechanical injury of the musculoskeletal system was developed and experimentally substantiated. The adequacy of this model for studies of morphological and functional regularities is verified. This model can be used for the development of a new concept of evaluation of thrombotic complications of mechanical injury.

Keywords: hyperhomocysteinemia; single nucleotide polymorphisms; thrombosis; vascular morphometry.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Genotype
  • Hyperhomocysteinemia / genetics
  • Hyperhomocysteinemia / pathology*
  • Hyperhomocysteinemia / physiopathology*
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Methylenetetrahydrofolate Reductase (NADPH2) / metabolism
  • Microcirculation / physiology*
  • Polymorphism, Single Nucleotide / genetics
  • Rats
  • Thrombosis / genetics
  • Thrombosis / physiopathology

Substances

  • Methylenetetrahydrofolate Reductase (NADPH2)