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. 2020 Feb;26(2):227-230.
doi: 10.1111/tbj.13544. Epub 2019 Sep 9.

Initial outcomes with image-guided partial breast irradiation delivered with intensity-modulated radiation therapy

Chirag Shah  1 , Elizabeth Obi  1 , Martin C Tom  1 , Bindu V Manyam  1 , Betty Obi  1 , Zahraa Al-Hilli  2 , Stephen Grobmyer  2 , Jame Abraham  1 , Ping Xia  1 , Eric Murray  1 , Sheen Cherian  1 , Rahul D Tendulkar  1
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Initial outcomes with image-guided partial breast irradiation delivered with intensity-modulated radiation therapy

Chirag Shah et al. Breast J. 2020 Feb.

Abstract

Patients were treated at a single institution to a dose of 30 Gy in five fractions delivered every other day using image-guided intensity modulated radiation therapy (IMRT) partial breast irradiation. A total of 34 patients were treated with a median follow-up of 4.6 months. The rate of acute Grade 1 dermatitis was 23.5% (n = 8), and Grade 1 fatigue was 17.6% (n = 6), with no Grade 2 or higher acute toxicities. The rate of chronic Grade 1 dermatitis was 25.0% (n = 6), Grade 1 fat necrosis 4.2% (n=1), with no patients demonstrating other chronic toxicities. Image-guided APBI delivered with IMRT is associated with low rates of acute and chronic toxicity though additional follow-up is warranted.

Keywords: breast cancer; breast conserving therapy; partial breast irradiation.

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