C-H and N-H bond annulation of aryl amides with unactivated olefins by merging cobalt(iii) and photoredox catalysis

Deepti Kalsi; Nagaraju Barsu; Sagnik Chakrabarti; Pardeep Dahiya; Magnus Rueping; Basker Sundararaju

doi:10.1039/c9cc05744g

C-H and N-H bond annulation of aryl amides with unactivated olefins by merging cobalt(iii) and photoredox catalysis

Chem Commun (Camb). 2019 Sep 24;55(77):11626-11629. doi: 10.1039/c9cc05744g.

Authors

Deepti Kalsi¹, Nagaraju Barsu¹, Sagnik Chakrabarti¹, Pardeep Dahiya¹, Magnus Rueping², Basker Sundararaju¹

Affiliations

¹ Department of Chemistry, Indian Institute of Technology Kanpur, 208016, India. basker@iitk.ac.in.
² Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen D-52074, Germany. magnus.rueping@rwth-aachen.de.

PMID: 31502608
DOI: 10.1039/c9cc05744g

Abstract

A mild, environment-friendly protocol has been developed to carry out the [4+2] annulation of aryl amides with unactivated olefins. A range of sterically and electronically diverse aryl amides and unactivated olefins were successfully employed under the developed conditions to get a variety of dihydroisoquinolinones in good-to-excellent yields.