Anti-β c mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model

Allergy. 2020 Feb;75(2):475-478. doi: 10.1111/all.14041. Epub 2019 Oct 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal / therapeutic use*
  • Cytokines / metabolism
  • Disease Models, Animal
  • Heterografts*
  • Humans
  • Mice
  • Mice, Transgenic
  • Nasal Polyps / complications*
  • Nasal Polyps / drug therapy*
  • Nasal Polyps / pathology
  • Receptors, Cytokine / immunology*
  • Rhinitis / complications*
  • Rhinitis / drug therapy*
  • Sinusitis / complications*
  • Sinusitis / drug therapy*
  • Th2 Cells / immunology
  • Transcriptome
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Cytokines
  • Receptors, Cytokine
  • beta C receptor