Carpal tunnel syndrome associated with sarcoidosis in identical twin patients

Monaldi Arch Chest Dis. 2019 Sep 10;89(3). doi: 10.4081/monaldi.2019.1089.


Sarcoidosis is a multisystemic disease that may lead to neurologic complications in 10% of the patients. Carpal tunnel syndrome is very rare in sarcoidosis. We present two identical twin sarcoidosis patients with carpal tunnel syndrome. A number of factors may cause carpal tunnel syndrome like wrist anatomy, occupation, diabetes, rheumatoid arthritis, pregnancy and renal failure. Although the above factors do not directly cause carpal tunnel syndrome, they may increase your chances of developing or aggravate median nerve damage as it is in sarcoidosis. Sarcoidosis relevant neuropathy and granulomas may be the primary mechanism of sarcoidosis associated carpal tunnel syndrome. Although rare, carpal tunnel syndrome may be a feature of sarcoidosis that may lead to irreversible damage in cases of delayed diagnosis. The presence of this syndrome in identical twin patients may shed light into the pathogenesis and the genetic transmission of sarcoidosis with the associated carpal tunnel syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alleles
  • Carpal Tunnel Syndrome / complications*
  • Carpal Tunnel Syndrome / genetics*
  • Female
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Polymorphism, Genetic
  • Sarcoidosis / complications*
  • Sarcoidosis / genetics*
  • Twins, Monozygotic / genetics


  • HLA-DRB1 Chains