Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019

Euro Surveill. 2019 Sep;24(36):1900528. doi: 10.2807/1560-7917.ES.2019.24.36.1900528.

Abstract

We report two cases of multidrug-resistant Neisseria gonorrhoeae urogenital infection with ceftriaxone resistance in a heterosexual couple in south-western France who were successfully treated with a single, high dose of intramuscular ceftriaxone (1 g). Whole genome sequencing of isolate F91 identified MLST13871, NG-MAST1086, NG-STAR233. Patient history revealed the isolate F91 was most likely acquired during a trip to Cambodia and belongs to the successful multidrug-resistant FC428 Asian clone.

Keywords: Gonorrhoea; antimicrobial resistance; high dose anti-microbial treatment; travel; whole-genome sequencing.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Azithromycin / therapeutic use
  • Back Pain / etiology
  • Cambodia
  • Ceftriaxone / therapeutic use
  • Drug Resistance, Multiple, Bacterial
  • Dysuria / etiology
  • France
  • Gonorrhea / diagnosis*
  • Gonorrhea / drug therapy
  • Heterosexuality
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / genetics*
  • Neisseria gonorrhoeae / isolation & purification*
  • Nucleic Acid Amplification Techniques
  • Travel
  • Treatment Outcome
  • Urethritis / drug therapy
  • Urethritis / microbiology
  • Whole Genome Sequencing

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone
  • Azithromycin