Abstract
We report two cases of multidrug-resistant Neisseria gonorrhoeae urogenital infection with ceftriaxone resistance in a heterosexual couple in south-western France who were successfully treated with a single, high dose of intramuscular ceftriaxone (1 g). Whole genome sequencing of isolate F91 identified MLST13871, NG-MAST1086, NG-STAR233. Patient history revealed the isolate F91 was most likely acquired during a trip to Cambodia and belongs to the successful multidrug-resistant FC428 Asian clone.
Keywords:
Gonorrhoea; antimicrobial resistance; high dose anti-microbial treatment; travel; whole-genome sequencing.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Azithromycin / therapeutic use
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Back Pain / etiology
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Cambodia
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Ceftriaxone / therapeutic use
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Drug Resistance, Multiple, Bacterial
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Dysuria / etiology
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France
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Gonorrhea / diagnosis*
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Gonorrhea / drug therapy
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Heterosexuality
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Humans
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Male
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Neisseria gonorrhoeae / drug effects
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Neisseria gonorrhoeae / genetics*
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Neisseria gonorrhoeae / isolation & purification*
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Nucleic Acid Amplification Techniques
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Travel
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Treatment Outcome
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Urethritis / drug therapy
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Urethritis / microbiology
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Whole Genome Sequencing
Substances
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Anti-Bacterial Agents
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Ceftriaxone
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Azithromycin