Parathyromatosis: a very rare cause of recurrent primary hyperparathyroidism - case report and review of the literature

Ann R Coll Surg Engl. 2019 Nov;101(8):e178-e183. doi: 10.1308/rcsann.2019.0105. Epub 2019 Sep 11.


Parathyromatosis is a rare entity and usually appears as a consequence of the seeding on previous parathyroid surgery which was applied for the secondary hyperparathyroidism. A 63-year-old woman presented with a history of subtotal thyroidectomy 20 years ago and parathyroidectomy due to primary hyperparathyroidism (PHPT) four years ago. Imaging methods revealed multiple parathyromatosis foci on subcutaneous tissue of the neck. En-bloc resection was performed and pathological examination confirmed the diagnosis of parathyromatosis. After an uneventful 10 months, biochemical and radiological tests revealed recurrence on bilateral thyroid lodges. En-bloc resection was performed. The patient has remained well for 24 months after the second operation and has been followed-up with normal parathormone and serum calcium values. To the best of our knowledge, this report describes the twenty-first case of parathyromatosis in PHPT setting in the literature. It should be kept in mind that parathyromatosis may recur at different sites in the neck even in patients with PHPT.

Keywords: Parathyroidectomy; Parathyromatosis; Primary hyperparathyroidism; Recurrent parathyromatosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Choristoma / complications*
  • Choristoma / diagnostic imaging
  • Choristoma / surgery
  • Female
  • Humans
  • Hyperparathyroidism, Primary / etiology*
  • Hyperparathyroidism, Primary / surgery
  • Middle Aged
  • Neck / diagnostic imaging
  • Parathyroid Glands*
  • Parathyroidectomy
  • Radionuclide Imaging
  • Recurrence
  • Subcutaneous Tissue / diagnostic imaging
  • Tomography, X-Ray Computed
  • Ultrasonography