Hypoxanthine and inosine analogues as chemotherapeutic agents in Chagas' disease

Mem Inst Oswaldo Cruz. 1988 Nov;83 Suppl 1:301-7. doi: 10.1590/s0074-02761988000500014.

Abstract

Analogues of purines, especially those of hypoxanthine and inosine, appear to hold considerable promise for the treatment of Chagas' disease.

MeSH terms

  • Animals
  • Chagas Disease / drug therapy*
  • Humans
  • Inosine / analogs & derivatives*
  • Inosine / therapeutic use
  • Pyrazoles / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Trypanocidal Agents / therapeutic use*

Substances

  • Pyrazoles
  • Pyrimidines
  • Trypanocidal Agents
  • Inosine
  • 9-deazainosine