Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

J Diabetes Res. 2019 Aug 14;2019:8562408. doi: 10.1155/2019/8562408. eCollection 2019.


Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM) causing vision impairment even at young ages. There are numerous mechanisms involved in its development such as inflammation and cellular degeneration leading to endothelial and neural damage. These mechanisms are interlinked thus worsening the diabetic retinopathy outcome. In this review, we propose oxidative stress as the focus point of this complication onset.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / therapeutic use*
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / pathology
  • Diabetic Retinopathy / drug therapy*
  • Diabetic Retinopathy / etiology*
  • Diabetic Retinopathy / metabolism
  • Disease Progression
  • Humans
  • Oxidative Stress / physiology*
  • Risk Factors
  • Vision, Ocular / drug effects
  • Vision, Ocular / physiology


  • Antioxidants