Large bowel tumor promotion by diamine oxidase inhibition: animal model and clinical aspects

Adv Exp Med Biol. 1988;250:745-52. doi: 10.1007/978-1-4684-5637-0_66.

Abstract

In the intestinal mucosa, diamine oxidase probably is involved in a feedback regulation mechanism for the termination of proliferation. This was proven by a considerable promotion of large bowel tumors induced by diamine oxidase inhibition in a rat model. Carcinogenesis was accompanied by characteristic alterations in mucosal diamine oxidase activity. In large bowel cancer patients similar changes in intestinal diamine oxidase activity had been observed as in the animal model.

Conclusion: Events entailing a reduction of diamine oxidase activity are suspicious for large bowel cancer promotion under experimental and clinical conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amine Oxidase (Copper-Containing) / antagonists & inhibitors*
  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell Division / drug effects
  • Disease Models, Animal
  • Female
  • Humans
  • Intestinal Mucosa / pathology
  • Intestinal Neoplasms / chemically induced*
  • Intestinal Neoplasms / drug therapy
  • Intestinal Neoplasms / enzymology
  • Male
  • Middle Aged
  • Rats
  • Rats, Inbred F344

Substances

  • Antineoplastic Agents
  • Amine Oxidase (Copper-Containing)