Serum vitamin D concentrations are inversely related to prevalence of metabolic syndrome in Qatari women

Biofactors. 2020 Jan;46(1):180-186. doi: 10.1002/biof.1572. Epub 2019 Sep 12.


Hypovitaminosis D has reached epidemic proportions in Qatar. Vitamin D is linked to several cardiometabolic diseases such as metabolic syndrome (MetSyn), diabetes, and atherosclerosis. It is not known if vitamin D status is linked to cardiometabolic risk factors in Qatari women. Therefore, a relationship between serum 25-hydroxyvitmain D [25(OH)D] concentrations and MetSyn was investigated in Qatari women using the Qatar Biobank database. Study sample consisted of 700 women, aged 20-80 years old. A multivariate-adjusted logistic regression was used to determine relation between serum 25(OH)D and MetSyn prevalence. Multivariate linear regression was performed to determine the association between serum 25(OH)D and markers of MetSyn. Prevalences of MetSyn in the first (≈32%), second (≈27%), and third (≈28%) serum 25(OH)D quartiles were significantly higher compared to fourth serum 25(OH)D quartile (≈17.5%) (p < .035). The likelihood of having MetSyn was significantly higher in the first serum 25(OH)D quartile (OR, 1.92; 95% CI, 1.06, 3.49) compared to the fourth serum 25(OH)D quartile (p < .001) in multivariate-adjusted analysis. No relationship was observed between serum 25(OH)D and waist circumference, blood pressure, glycated hemoglobin (HbA1C), blood glucose, HDL-cholesterol, and serum triglycerides. This study showed an inverse relationship between prevalence of MetSyn and serum 25(OH)D in Qatari women. Given the widespread prevalence of vitamin D deficiency in Qatar, consideration should be given to vitamin D fortification of some selected staple foods and through targeted supplementation of vitamin D in those who are at risk for cardiometabolic diseases.

Keywords: 25-Hydroxyvitmain D, metabolic syndrome; Qatar, Qatar biobank; postmenopausal women; vitamin D.

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Female
  • Humans
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / epidemiology*
  • Prevalence
  • Qatar / epidemiology
  • Risk Factors
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / epidemiology*


  • Vitamin D