Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec 1;183:111660.
doi: 10.1016/j.ejmech.2019.111660. Epub 2019 Aug 29.

Multi-target Drugs Active Against Leishmaniasis: A Paradigm of Drug Repurposing

Affiliations
Review

Multi-target Drugs Active Against Leishmaniasis: A Paradigm of Drug Repurposing

Susana Santos Braga. Eur J Med Chem. .

Abstract

This mini-review focuses on leishmanicidal drugs that were sourced from small molecules previously approved for other diseases. The mechanisms of action of these molecules are herein explored, to probe the origins of their inter-species growth inhibitory activities. It is shown how the transversal action of the azoles - fluconazole, posaconazole and itraconazole - in both fungi and Leishmania is due to the occurrence of the same target, lanosterol 14-α-demethylase, in these two groups of species. In turn, the drugs miltefosine and amphotericin B are presented as truly multi-target agents, acting on small molecules, proteins, genes and even organelles. Steps towards future leishmanicidal drug candidates based on the multi-target strategy and on drug repurposing are also briefly presented.

Keywords: Amphotericin B; Fluconazole; Itraconazole; Leishmanicidal drugs; Miltefosine; Posaconazole.

Similar articles

See all similar articles

Cited by 1 article

MeSH terms

Feedback